Yeah, I would say that surgical planning is a key point, and it’s a little bit different from other situations in surgical oncology. I think that the most important point is to have a deep knowledge of the biology of the tumor. So we behave very differently, whether you have liposarcoma or leiomyosarcoma. I took these examples, but even in case of liposarcoma, it’s very different than the expected outcome in case of well-differentiated or dedifferentiated tumors...
Yeah, I would say that surgical planning is a key point, and it’s a little bit different from other situations in surgical oncology. I think that the most important point is to have a deep knowledge of the biology of the tumor. So we behave very differently, whether you have liposarcoma or leiomyosarcoma. I took these examples, but even in case of liposarcoma, it’s very different than the expected outcome in case of well-differentiated or dedifferentiated tumors. So, this helps to target the extent of surgery. We cannot imagine for liposarcomas that are tumors, I mean, usually very big. You can have a median 8 to 10 centimeters of the maximum tumor diameter, but you can reach also, and this is quite common, 30, 40 centimeters of tumors. So you cannot imagine to have a real, complete radical excision, as we call R0, so we assume that this kind of procedure is R1 by definition because in some point you will reach the tumor, but beside that, we know that the surrounding organs can be infiltrated, maybe not directly from the tumor, but the perivisceral tissues, the perivisceral fat, in case of colon, or also the distal pancreas and the kidney, especially is affected by tumor at the microscopic extent. So that’s why we suggest that, in general speaking, the surrounding organs are resected in case of liposarcoma.
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