Bruna Pellini, MD, Moffitt Cancer Center, Tampa, FL, reflects on the use of circulating tumor DNA (ctDNA) and its applications, including molecular profiling in advanced disease, as well as guiding treatment decisions. Dr Pellini also speaks on minimal residual disease (MRD) evaluation, its role in colorectal cancer, and potential in other solid tumors. This interview took place at the American Society of Clinical Oncology (ASCO) 2022 Annual Meeting in Chicago, IL.