Bruna Pellini, MD, Moffitt Cancer Center, Tampa, FL, reviews evidence avialble regarding circulating tumor DNA (ctDNA) minimal residual disease (MRD) of non-small cell lung cancer (NSCLC) treated with curative intent, as well as prospective studies in this patient population. This interview took place at the American Society of Clinical Oncology (ASCO) 2022 Annual Meeting in Chicago, IL.