IASLC TTLC 2024 | Evaluating the use of ctDNA as a biomarker in lung cancer

Bruna Pellini, MD, H. Lee Moffitt Cancer Center, Tampa, FL, discusses the emerging role of circulating tumor DNA (ctDNA) as a biomarker of progression in lung cancer. Findings from the Phase III EMPOWER-Lung 1 trial (NCT03088540) of cemiplimab monotherapy in patients with non-small cell lung cancer (NSCLC) concluded that treatment outcomes were reflected in differences in ctDNA levels. The Phase III IMpower 131 trial (NCT02367794) of atezolizumab with platinum-based chemotherapy additionally demonstrated that ctDNA can stratify patients based on disease risk after three cycles of treatment. This interview took place at 2024 Targeted Therapies of Lung Cancer Meeting (TTLC 2024) in Santa Monica, CA.

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