BNOS 2022 | Is glioma cell invasion dependent on the DNA damage response kinase ATR?

Ross Carruthers, PhD, University of Glasgow, Glasgow, UK, discusses ATR-dependent glioma cell invasion. DNA replication stress, which is a frequent occurrence in cancer cells such as glioma, may arise as a result of conflicts in transcription, insufficient of DNA material or overexpression of oncogenes. The phenomenon additionally drives resistance to radiotherapy, as well as upregulate expression of ATR, a DNA damage response kinase, which can also drive glioma cell invasion into other areas of the brain. Radiosensitization therapy may consequently have the potential to limit the spread of glioma. This interview took place at the British Neuro-Oncology Society (BNOS) Annual Meeting 2022.