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SABCS 2022 | Systemic immune response to durvalumab concomitant with neoadjuvant chemotherapy in early stage TNCB

Kim Blenman, PhD, MS, Yale School of Medicine, New Haven, CT, talks on a an investigation into the systemic immune response to a Phase I/II trial (NCT02489448) of durvalumab concomitant with neoadjuvant chemotherapy in early stage triple-negative breast cancer (TNCB). 38 serum cytokines and the peripheral blood T-cell receptor (TCR) immune repertoire of 66 patients with TNBC we evaluated for associations with pathologic complete response (pCR), pre- and post-treatment phase, and immune related treatment emergent adverse events. Specific subsets of cytokines were found to be associated with residual disease and pCR. Additionally, specific immune-related cytokines and chemokines were found to be associated with immune-related adverse events. This interview took place at the San Antonio Breast Cancer Symposium (SABCS) 2022 in San Antonio, TX.

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