Melissa Johnson, MD, Sarah Cannon Research Institute, Nashville, TN, discusses two key clinical trials evaluating the TROP2-directed antibody-drug conjugate (ADC) datopotamab deruxtecan (Dato-DXd) in patients with non-small cell lung cancer (NSCLC). Dato-DXd is currently being compared to docetaxel in the TROPION-Lung01 Phase III study (NCT04656652) and it is expected that the results from this study will lead to the approval of this ADC for NSCLC in the second-line setting. In addition, the TROPION-Lung05 Phase II study (NCT04484142) is assessing the efficacy of Dato-DXd in patients with NSCLC with actionable genomic alterations previously treated with tyrosine kinase inhibitors (TKIs) or chemotherapy. This interview took place at the World Conference on Lung Cancer (WCLC) 2021.