SABCS 2024 | TIME and estrogen deprivation resistance in HR+ breast cancer

Fabiana Napolitano • 13 Dec 2024

SABCS 2024

Breast Cancer

Fabiana Napolitano, MD, University of Naples Federico II, Naples, Italy, discusses the role of the tumor immune microenvironment (TIME) in resistance to estrogen deprivation therapy in hormone receptor (HR)-positive breast cancer. CD8+ T cell infiltration and chemokine enrichment, particularly CXCL11, were associated with estrogen deprivation resistance. CXCL11 promotes estrogen-independent proliferation via CXCR3 signaling, contributing to shorter relapse-free survival. This interview took place at the 2024 San Antonio Breast Cancer Symposium (SABCS) congress in San Antonio, TX.

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