Benjamin Schlechter, MD, Dana-Farber Cancer Institute, Boston, MA, discusses findings from the Phase I TACTIC-2 trial (NCT04727151) of TAC01-HER2, a novel HER2-directed TAC T-cell therapy, in solid tumors. The investigational cellular therapy was found to be safe in patients, and efficacious in gastroesophageal junction (GEJ) cancer but not in breast cancer. Potential reasons include the small, pretreated cohort, and the tumor microenvironment. A Phase II trial with the addition of checkpoint inhibitors is planned in patients with GEJ cancer. This interview took place at the American Society of Clinical Oncology (ASCO) 2023 Annual Congress in Chicago, IL.
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