Samuel Klempner, MD, Massachusetts General Hospital, Boston, MA, provides an overview of advances in the management of gastric and gastroesophageal cancer (GC/GEJC). Triplet combinations incorporating existing regimens such as fluorouracil and platinum chemotherapy have shown encouraging efficacy in the KEYNOTE-811 trial (NCT03615326). Discovery of novel biomarkers such as FGFR2 will additionally enable patients access to efficacious treatment, and findings from the KEYNOTE-585 (NCT03221426) and CheckMate 577 (NCT02743494) trials have shown promising results for perioperative immunotherapy. The INFINITY (NCT04817826) and GERCOR NEONIPIGA (NCT04006262) studies have also provided updates in microsatellite instability high GC/GEJC. This interview took place at the American Society of Clinical Oncology (ASCO) 2023 Gastrointestinal Cancers (GI) Symposium in San Francisco, CA.
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