SABCS 2024 | Elucidating immune signatures in breast cancer brain metastases
Anna Thulin, MD, PhD, University of Gothenburg, Gothenburg, Sweden, discusses the differences in gene expression and immune microenvironment signatures between brain metastases and primary breast tumors in breast cancer. Findings reveal significant downregulation of immune-related signatures in brain metastases compared to primary tumors. The reduced immunogenicity of brain metastases may explain the limited efficacy of immune checkpoint inhibitors intracranially, highlighting the need for novel treatment strategies. This interview took place at the 2024 San Antonio Breast Cancer Symposium (SABCS) congress in San Antonio, TX.
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