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ASCO GI 2023 | STELLAR-303: XL092 with atezolizumab or regorafenib in patients with mCRC

J. Randolph Hecht, MD, University of California, Los Angeles, CA, describes the trial design and rationale of the Phase III STELLAR-303 (NCT05425940) of XL092 with atezolizumab or regorafenib in pre-treated patients with microsatellite stable/microsatellite instability low (MSS/MSI-low) metastatic colorectal cancer, a group of patients with limited treatment options. Previous studies have shown oral tyrosine kinase inhibitors (TKI) such as cabozantinib to have encouraging efficacy, and XL092 is a novel TKI under investigation. This interview took place at the American Society of Clinical Oncology (ASCO) 2023 Gastrointestinal Cancers (GI) Symposium in San Francisco, CA.

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