ELCC 2024 | Post-progression analysis of MARIPOSA-2: amivantamab + chemo in EGFR+ NSCLC

Alexander Spira, MD, PhD, FACP, Next Oncology-Virginia VCS, Fairfax, VA, discusses the Phase III MARIPOSA-2 (NCT04988295) trial, which explored the effectiveness of amivantamab in combination with carboplatin-pemetrexed with or without lazertinib in patients with EGFR-mutated advanced non-small cell lung cancer (NSCLC) who had experienced disease progression on osimertinib. Key findings included significant progression-free survival benefits at 6 and 12 months, improved time-to-treatment discontinuation (TTD), and time to subsequent therapy. Dr Spira also discusses post-progression outcomes, highlighting prolonged frontline therapy duration and improved progression-free survival (PFS) after subsequent therapy in the amivantamab plus chemotherapy arm. The study suggests that chemotherapy may represent a new standard of care for patients after osimertinib progression. This interview took place at the ELCC 2024 meeting in Prague, Czech Republic.

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