Axel S. Merseburger, MD, Universitätsklinikum Schleswig-Holstein, Campus Lübeck, Lübeck, discusses advances in novel biomarkers for precision medicine in prostate cancer, including modern technologies to uncover biomarkers such as whole genome sequencing, circulating tumor cells (CTCs) and cell-free DNA (cfDNA), as well as artificial intelligence (AI). This interview took place at the American Society of Clinical Oncology (ASCO) Genitourinary Cancers Symposium 2022 in San Francisco, CA.