Sophia Kamran, MD, Massachusetts General Hospital, Boston, MA, talks on the future of radiation therapy for urothelial carcinoma, including hypofractionated radiation therapy, adaptive radiation therapy and personalizing radiation therapy. Additionally, radiation in combination with immunotherapy and other novel therapies is discussed. This interview took place at the American Society of Clinical Oncology (ASCO) Genitourinary Cancers Symposium 2022 in San Francisco, CA.