Yeah. So, there are many different options here. This is the huge question in colorectal cancer as the majority of the microenvironment is very cold. And so, I think we highlight here one strategy where we try to change the tumor microenvironment. But there are others that look at the VEGF pathway, look at novel TKI targeting, also look at CAR-T-cells and actually the development of Neo-antigen vaccine-based opportunities as well to in combination with checkpoint inhibition...
Yeah. So, there are many different options here. This is the huge question in colorectal cancer as the majority of the microenvironment is very cold. And so, I think we highlight here one strategy where we try to change the tumor microenvironment. But there are others that look at the VEGF pathway, look at novel TKI targeting, also look at CAR-T-cells and actually the development of Neo-antigen vaccine-based opportunities as well to in combination with checkpoint inhibition. So, all of these rationale trying to find a way to turn this cold environment into a hot environment that’s responsive to immunotherapy.