ESMO WCGIC 2023 | Evaluating the optimal approach for managing MSI-H upper GI cancers

Filippo Pietrantonio, MD, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy, comments on key considerations in treating high microsatellite instability (MSI-H) gastric and esophagogastric junction (GEJ) cancers. Surgery has typically resulted in favorable outcomes over microsatellite stable upper gastrointestinal (GI) cancers, and neoadjuvant immunotherapy has proven to be efficacious in the metastatic setting. The Phase II INFINITY trial (NCT04817826) additionally suggests that chemotherapy or surgery may be omitted in this setting as well. Further biomarker research is also needed to identify patients who may progress on immunotherapy. This interview took place at the ESMO World Congress on Gastrointestinal Cancer (WCGIC) 2023 in Barcelona, Spain.

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