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ESMO 2025 | Elucidating the most significant factors on survival from cachexia

Lynn Gottmann, Medical University of Vienna, Vienna, Austria, discusses the definition and impact of cancer-associated cachexia, highlighting five cachexia-associated factors, including GDF-15, modified Glasgow prognostic score, weight loss, loss of appetite, and low skeletal muscle index, which cumulatively affect overall survival. The modified Glasgow prognostic score, GDF-15, and weight loss had the most significant impact on overall survival. This interview took place at the European Society for Medical Oncology (ESMO) 2025 Congress in Berlin, Germany.

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Transcript

In the literature, cancer-associated cachexia is defined in many different ways. For my talk, I looked at five different cachexia-associated factors. GDF 15, modified Glasgow prognostic score, weight loss, loss of appetite, and low skeletal muscle index. And we saw Modified Glasgow Prognostic Score, GDF 15 and weight loss have a significant impact on overall survival and when you look at all five factors you will see that they cumulatively impact overall survival...

In the literature, cancer-associated cachexia is defined in many different ways. For my talk, I looked at five different cachexia-associated factors. GDF 15, modified Glasgow prognostic score, weight loss, loss of appetite, and low skeletal muscle index. And we saw Modified Glasgow Prognostic Score, GDF 15 and weight loss have a significant impact on overall survival and when you look at all five factors you will see that they cumulatively impact overall survival.

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