Sherene Loi, MBBS, PhD, FRACP, FAHMS, Peter MacCallum Cancer Centre at the University of Melbourne, Melbourne, Australia, shares her highlights from the St Gallen International Expert Consensus 2021. Prof. Loi notes the debates surrounding anthracycline omission in HER2-positive breast cancer as an important development, as well as discussions on the importance of chemotherapy for premenopausal women with hormone-responsive breast cancer. This interview took place during the 17th St. Gallen International Breast Cancer Conference.