Current hurdles in developing CAR-T therapies for gastrointestinal tumors
J. Randolph Hecht, MD, University of California, Los Angeles, CA, comments on remaining challenges in the field of CAR-T and cellular therapies for gastrointestinal malignancies. On-target, off-tumor toxicities remain an issue, where targets such as mesothelin are widespread in the body and are not necessarily tumor-specific. This interview took place at the American Society of Clinical Oncology (ASCO) 2023 Gastrointestinal Cancers (GI) Symposium in San Francisco, CA.
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