Filippo Pietrantonio, MD, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy, discusses the development of novel targeted therapies for gastric cancer. In addition to microsatellite instability (MSI) high and PD-L1, claudin 18.2 and FGFR2b have been identified as promising targets. Zolbetuximab, and anti-claudin 18.2 antibody has improved survival in patients with gastric cancer in the Phase III SPOTLIGHT trial (NCT03504397). Bemarituzumab has additionally validated FGFR2b as a target in the first-line setting. This interview took place at the ESMO World Congress on Gastrointestinal Cancer (WCGIC) 2023 in Barcelona, Spain.
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