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AACR 2025 | Novel approaches to testing neoadjuvant bladder cancer therapies

Bishoy Faltas, MD, Weill Cornell Medicine, New York, NY, comments on the potential of a neoadjuvant platform for testing novel therapies in patients with precursor conditions, highlighting the value of circulating tumor DNA (ctDNA) and urine cell-free DNA in understanding the biology and effects of treatments. This approach can be informative in terms of developing novel therapies or therapy combinations. This interview took place at American Association for Cancer Research (AACR) Annual Meeting 2025 in Chicago, IL.

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Transcript

So we think that this window of opportunity neoadjuvant platform is really promising for testing novel therapies. We have been able to establish organoids, patient-derived xenografts, we have circulating tumor DNA (ctDNA), we have urine cell-free DNA, and we have analyzed all of that and we’re continuing to analyze this data. It gives us really a wealth of information and understanding of the biology that helps us understand the effects of the drug and test novel therapies or novel therapy combinations in this clinical setting...

So we think that this window of opportunity neoadjuvant platform is really promising for testing novel therapies. We have been able to establish organoids, patient-derived xenografts, we have circulating tumor DNA (ctDNA), we have urine cell-free DNA, and we have analyzed all of that and we’re continuing to analyze this data. It gives us really a wealth of information and understanding of the biology that helps us understand the effects of the drug and test novel therapies or novel therapy combinations in this clinical setting.

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