The American Association for Cancer Research (AACR) Annual Meeting 2025 serves as a key gathering point for the global cancer research community, uniting scientists, clinicians, healthcare professionals, survivors, patients, and advocates to share the latest advances in cancer science and medicine. Spanning topics from population science and prevention to cancer biology, translational and clinical research, survivorship, and advocacy, the 2025 Meeting in Chicago highlights ground-breaking work from leading researchers around the world.