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BCC 2021 | monarchE: adjuvant abemaciclib in HR+ breast cancer

Sara Tolaney, MD, MPH, Dana-Farber Cancer Institute, Boston, MA, describes the results of monarchE (NCT03155997), a Phase III study evaluating the use of endocrine therapy with or without abemaciclib, a CDK4/6 inhibitor following surgery in patients with high-risk, node-positive, early-stage, hormone receptor-positive (HR+) breast cancer. The results of this study suggest that the abemaciclib treatment arm showed improved outcomes in patients with hormone-receptor-positive breast cancer. This interview took place during the 17th St. Gallen International Breast Cancer Conference.

Disclosures

Institutional Research Funds: AstraZeneca, Lilly, Merck, Nektar, Novartis, Pfizer, Genentech/Roche, Immunomedics/Gilead, Exelixis, Bristol-Myers Squibb, Eisai, Nanostring, Cyclacel, Sanofi, Odonate, Seattle Genetics
Honoraria: AstraZeneca, Lilly, Merck, Nektar, Novartis, Pfizer, Genentech/Roche, Immunomedics/Gilead, Bristol-Myers Squibb, Eisai, Nanostring, Puma, Sanofi, Odonate, Seattle Genetics, Daiichi Sankyo, Athenex, OncoPep, Kyowa Kirin Pharmaceuticals, Kyowa Kirin Pharmaceuticals, CytomX, Certara, Mersana Therapeutics