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AACR 2021 | Heritability of cancer predisposition gene mutations in neuroblastoma

Emily Blauel, MD, Children’s Hospital of Philadelphia, Philadelphia, PA, talks on the heritability of cancer predisposition gene mutations in neuroblastoma patients, outlining data from an analysis of 556 patients with paired parental DNA whole genome sequences. The analysis reported that around 13.5% of patients with neuroblastoma had a rare P/LP germline variant of cancer predisposition genes, and that germline P/LP variants were associated with high-risk disease. This interview took place at the virtual American Association for Cancer Research (AACR) Annual Meeting 2021.

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