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ESMO Breast 2025 | Evaluating the role of combination therapies in invasive lobular carcinoma

Soraia Lobo-Martins, MD, Institut Jules Bordet, Brussels, Belgium, emphasizes the importance of neoadjuvant endocrine therapy in the treatment of endocrine-sensitive tumors in breast cancer, suggesting that a minimum of six months of therapy may be necessary for optimal results. Combining endocrine therapy with other agents is additionally suggested, such as ROS1 inhibition, to achieve better outcomes, as seen in the REPLOT trial (NCT06408168). This interview took place at the 2025 European Society for Medical Oncology (ESMO) Breast Cancer Annual Congress in Munich, Germany.

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Transcript

So I do believe that endocrine therapy is the key backbone to work with the neoadjuvant setting. We’ve been seeing that the four months that we did in this trial, maybe it’s too short. So for future trials, I would advise anyone that it’s developing, and we are considering this in our team also, to go with at least six months of neoadjuvant endocrine therapy...

So I do believe that endocrine therapy is the key backbone to work with the neoadjuvant setting. We’ve been seeing that the four months that we did in this trial, maybe it’s too short. So for future trials, I would advise anyone that it’s developing, and we are considering this in our team also, to go with at least six months of neoadjuvant endocrine therapy. That would be one of the key points and one of the key messages for the future. The other lesson learned is that endocrine therapy alone doesn’t seem to work, so we’re trying to find the best partners. We have seen several attempts here when we saw the ROS1 inhibition. Let’s see what Jason Mouabbi can do in the advanced setting with the REPLOT study.

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