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ELCC 2025 | Invasive mediastinal re-staging after neoadjuvant therapy in NSCLC

Paul van Schil, MD, PhD, University Hospital Antwerp, Antwerp, Belgium, emphasizes the importance of restaging the mediastinum after neoadjuvant therapy for non-small cell lung cancer (NSCLC), particularly for patients with persistent N2 disease. This approach can significantly improve patient outcomes, as evidenced by studies from earlier trials such as EORTC 08941 (NCT00002623) and Intergroup 0139, and suggests that radiotherapy may be a more effective treatment option than surgical resection for patients with persistent N2 disease. This interview took place at the European Lung Cancer Congress (ELCC) 2025 in Paris, France.

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