Brian A. Van Tine, MD, PhD, Washington University School of Medicine in St.Louis, St Louis, MO, discusses results from a Phase I study (NCT04029922) of MT-511, a novel shiga toxin-conjugated recombinant fusion protein targeting HER2 in HER2-expressing solid tumors. The investigational therapy is well tolerated to-date with no clinically significant immuno- and cardiotoxicity, with the dose-escalation portion of the trial currently being conducted. This interview took place at the American Society of Clinical Oncology (ASCO) 2022 Annual Meeting in Chicago, IL.