ESMO 2023 | Phase III THOR study: erdafitinib vs. pembrolizumab in FGFR-altered advanced or metastatic UC

Arlene O. Siefker-Radtke, MD, MD Anderson Cancer Center, Houston, TX, discusses the randomized, open-label Phase III THOR study (NCT03390504) trial which evaluated the efficacy of erdafitinib versus pembrolizumab in pre-treated patients with advanced or metastatic urothelial cancer (UC) who harbored selected fibroblast growth factor receptor alterations (FGFRalt) and were anti-PD-(L)1-naïve. The primary endpoint was not met, with no statistically significant difference in overall survival (OS) between the two treatment arms. The erdafitinib arm exhibited a numerically longer progression-free survival (PFS) and numerically higher objective response rate (ORR), but a shorter duration of response. The most common treatment-related adverse events in the erdafitinib arm included hyperphosphatemia, stomatitis, and diarrhea; and in the pembrolizumab arm, pruritus, asthenia, and hypothyroidism. This interview took place at the European Society for Medical Oncology (ESMO) 2023 Congress in Madrid, Spain.

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