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WCLC 2024 | Developments and challenges in MET targeting for lung cancer

Alexander Spira, MD, PhD, Virginia Cancer Specialist, Fairfax, VA, comments the growing significance of MET as a therapeutic target in lung cancer. Dr Spira emphasizes the emergence of EGFR-MET bispecific antibodies like amivantamab and ABBV-400 in clinical studies. He also discusses the complexities of exon 14 skipping mutations, noting capmatinib and tepotinib as effective treatments. Ongoing research is exploring MET-targeting compounds in various tumour types, including gastric, colorectal, and head and neck cancers. This interview took place at the 2024 World Conference on Lung Cancer (WCLC) in San Diego, CA.

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