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ESMO 2025 | What will be practical uses of multi-cancer early detection in oncology?

Nima Nabavizadeh, MD, Oregon Health & Science University, Portland, OR, comments on the potential clinical application of multi-cancer early detection (MCED) tests for cancer screening, particularly for cancers without established screening strategies, such as liver, cholangiocarcinoma, and head and neck cancers. These tests can facilitate earlier cancer detection, leading to improved treatment outcomes, and may also serve as a complementary tool to existing screening methods like mammography and colonoscopy. This interview took place at the European Society for Medical Oncology (ESMO) 2025 Congress in Berlin, Germany.

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Transcript

I envision these MCED tests being used in the clinic for cancer screening, certainly to fill that unmet kind of gap for cancer screening for all those cancers that we don’t have recommended screening strategies for, you know, liver cancers, cholangiocarcinomas, head and neck cancers, you know, certainly with the hope that we would identify these cancers at an earlier stage, at which point treatment would be easier and outcomes would be better...

I envision these MCED tests being used in the clinic for cancer screening, certainly to fill that unmet kind of gap for cancer screening for all those cancers that we don’t have recommended screening strategies for, you know, liver cancers, cholangiocarcinomas, head and neck cancers, you know, certainly with the hope that we would identify these cancers at an earlier stage, at which point treatment would be easier and outcomes would be better. I don’t envision this MCED test as a replacement for a mammography or colonoscopy, but used in a complementary fashion in addition to those screening tests, again, to help fill that unmet need.

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