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ASCO GI 2023 | DKN-01 with bevacizumab and chemotherapy in advanced CRC

Zev Wainberg, MD, University of California Los Angeles, Los Angeles, CA, provides an overview of the trial design and rationale of the Phase II DeFianCe study (NCT05480306) of second-line DKN-01, an anti-DKK-1 monoclonal antibody, in combination with standard of care bevacizumab, FOLFIRI, and FOLFOX in patients with second-line colorectal cancer (CRC). Patients received either received the investigational therapy or bevacizumab and chemotherapy alone, where the primary endpoint was progression-free survival. This interview took place at the American Society of Clinical Oncology (ASCO) 2023 Gastrointestinal Cancers (GI) Symposium in San Francisco, CA.

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