Zev Wainberg, MD, University of California Los Angeles, Los Angeles, CA, provides an overview of the trial design and rationale of the Phase II DeFianCe study (NCT05480306) of second-line DKN-01, an anti-DKK-1 monoclonal antibody, in combination with standard of care bevacizumab, FOLFIRI, and FOLFOX in patients with second-line colorectal cancer (CRC). Patients received either received the investigational therapy or bevacizumab and chemotherapy alone, where the primary endpoint was progression-free survival. This interview took place at the American Society of Clinical Oncology (ASCO) 2023 Gastrointestinal Cancers (GI) Symposium in San Francisco, CA.
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