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ASCO 2025 | Rising toll of alcohol-related cancer mortality in the US: trends across age and sex groups

Chinmay Jani, MBBS, Sylvester Comprehensive Cancer Center, Doral, FL, comments on the alarming rise in alcohol-related cancer mortality in the US, stating that the number of alcohol-associated cancer deaths has doubled from 12,000 to over 23,000 in the past three decades, with increasing mortality rates across various age and sex groups. Dr Jani highlights that alcohol’s impact on cancer is constantly increasing, with a significant rise in proportional mortality rates across all age groups and sex groups except for elderly liver cancer. This interview took place during the 2025 American Society of Clinical Oncology (ASCO) Meeting in Chicago, IL.

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Transcript

So it was a very unique study that we were inspired by lots of risk factors and associations with cancer and the recent former US Surgeon General who sent out the guidelines advocating and guiding creating awareness about the alcohol and cancer association. So based on that we looked into the global burden of disease database and we wanted to analyze how mortality is impacting based on the alcohol-associated cancer...

So it was a very unique study that we were inspired by lots of risk factors and associations with cancer and the recent former US Surgeon General who sent out the guidelines advocating and guiding creating awareness about the alcohol and cancer association. So based on that we looked into the global burden of disease database and we wanted to analyze how mortality is impacting based on the alcohol-associated cancer. So using the database itself, there were around eight cancers which we were able to look into and over the past three decades, the number of alcohol-associated cancer deaths have doubled, which means alcohol leading to cancer and those cancers’ mortality has doubled almost from 12,000 to like 23,000 plus, which is quite concerning. When we looked into absolute rates for most of the cancers, we also stratified based on age and sex. And again, for most of the age and sex groups, it was varying but increasing in the recent years for many of those groups as well. The most impactful thing that we found was when we looked into proportional mortality rate which means alcohol as a proportion of risk factor leading to this cancer death as a risk factor it has increased for almost all age groups and all sex groups except just maybe liver for elderly people but that is quite concerning which means alcohol’s impact on cancer is constantly increasing over the past three decades in the United States.

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