Filippo Pietrantonio, MD, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy, highlights the importance of biomarkers in selecting patients for dual trastuzumab and pembrolizumab therapy in gastric cancer or gastroesophageal junction (G/GEJ) cancer. Targeted patient selection could enable de-escalation of chemotherapy, minimizing side effects while maintaining efficacy. With the rapidly evolving first-line treatment landscape, agents like claudin 18.2 and FGFR monoclonal antibodies are emerging. interview took place at the European Society for Medical Oncology (ESMO) 2024 Congress in Barcelona, Spain.
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