DESTINY-Breast02 was a trial that was pretty much done concurrent with DESTINY-Breast03. DESTINY-Breast02 looked at trastuzumab deruxtecan for patients with HER2-positive breast cancer that essentially were third-line and beyond and it was randomized against treatment of physician’s choice and these really were capecitabine with HER2 targeted agent combos.
What we saw was a statistically significant improvement in progression-free survival of essentially almost a year...
DESTINY-Breast02 was a trial that was pretty much done concurrent with DESTINY-Breast03. DESTINY-Breast02 looked at trastuzumab deruxtecan for patients with HER2-positive breast cancer that essentially were third-line and beyond and it was randomized against treatment of physician’s choice and these really were capecitabine with HER2 targeted agent combos.
What we saw was a statistically significant improvement in progression-free survival of essentially almost a year. This would’ve been extremely exciting and it still is exciting, but it kind of is put in perspective from the fact that we now have DESTINY-Breast03 data and approval for trastuzumab deruxtecan in the second-line setting. So, realistically, people are probably going to get trastuzumab deruxtecan in the second-line and not the third-line, and so that’s the only thing that kind of tempers these results, is now that we have access to trastuzumab deruxtecan earlier, it’s probably going to be used less in the later line.