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SABCS 2023 | The landscape of oral SERDs and their potential in ER+ breast cancer

Erika Hamilton, MD, from Sarah Cannon Research Institute in Nashville, TN, discusses the landscape of oral Selective Estrogen Receptor Degraders (SERDs) and their potential in ER+ breast cancer. These compounds work by degrading the estrogen receptor, providing a new endocrine backbone for treating ER-positive breast cancer. Notable developments include elacestrant, FDA-approved for patients with ESR1 mutations, and positive data from camizestrant, which is in confirmatory trials. Trials are exploring the use of SERDs post-CDK4/6 inhibitors, in combination with CDK4/6 inhibitors in the first-line setting, and in adjuvant therapy, either upfront or as a switch strategy. These advancements offer exciting prospects for treating ER+ breast cancer. This interview took place at the 2024 ASCO Gastrointestinal (GI) Cancers Symposium in San Francisco, CA.

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