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ASCO 2025 | The future landscape of treatment intensification strategies for TNBC

Christian Singer, Medical University of Vienna, Vienna, Austria, highlights the challenges of post-neoadjuvant achievement treatments in patients triple-negative breast cancer (TNBC) who haven’t achieved complete or near complete pathological remission. The debate on this topic is ongoing and that more research is needed to develop effective therapies for non-BRCA positive patients. This interview took place during the 2025 American Society of Clinical Oncology (ASCO) Meeting in Chicago, IL.

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Transcript

I think this is a difficult question. We haven’t really looked into this. We’re talking about post-neoadjuvant achievement treatments. We’re talking about treatments in patients who haven’t achieved complete or near complete pathological remission. And this is still something that needs to be debated. We have, of course, olaparib in BRCA positive tumors, which is already registered and which is a therapy of choice...

I think this is a difficult question. We haven’t really looked into this. We’re talking about post-neoadjuvant achievement treatments. We’re talking about treatments in patients who haven’t achieved complete or near complete pathological remission. And this is still something that needs to be debated. We have, of course, olaparib in BRCA positive tumors, which is already registered and which is a therapy of choice. We also have oral chemotherapies, but we don’t really know how to tackle the non-pCR achieving patients if they are not BRCA positive. I think that’s something that needs to be further elaborated, that needs to be further studied.

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Disclosures

Honoraria – AstraZeneca/MedImmune; Daiichi Sankyo Europe GmbH; Novartis
Consulting or Advisory Role – AstraZeneca/MedImmune; Daiichi-Sanyko; Gilead Sciences; Novartis; Sanofi/Aventis
Speakers’ Bureau – AstraZeneca/MedImmune; Novartis
Research Funding – Amgen; Amgen; AstraZeneca/MedImmune; Myriad Genetics; Novartis; Roche; Sanofi
Travel, Accommodations, Expenses – Daiichi-Sankyo; Gilead Sciences; Novartis; Roche