ASCO 2023 | Phase I trial of BI 764532, a T-cell engager for DLL3-positive NEC and SCLC

Martin Wermke, MD, University Hospital Carl Gustav Carus, Dresden, Germany, presents findings from a Phase I trial (NCT04429087) of BI 764532, a DLL3/CD3 IgG-like T-cell engager, in patients with DLL3-positive small-cell lung cancer (SCLC) and neuroendocrine carcinoma (NEC). Encouraging efficacy signals were reported, and duration of response (DOR) has not yet been reached. The T-cell engager additionally has an acceptable safety profile, where the adverse events reported did not hinder dose escalation efforts. This interview took place at the American Society of Clinical Oncology (ASCO) 2023 Annual Congress in Chicago, IL.

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