ASCO 2024 | Melanoma trials at ASCO 2024: KEYMAKER-U02A, IMC-F106 and SC-682
Meredith McKean, MD, MPH, Sarah Cannon Research Institute, Nashville, TN, gives an overview of key melanoma trials at the 2024 American Society of Clinical Oncology (ASCO) Meeting. The Phase I/II KEYMAKER-U02A trial (NCT04305041) assessed combination therapies for anti-PD-(L)1-refractory melanoma. Patients received either pembrolizumab with quavonlimab and vibostolimab, pembrolizumab with quavonlimab and lenvatinib, or pembrolizumab with ATRA. Findings from the Phase I trial (NCT04262466) assessing IMC-F106C, a novel ImmTAC bispecific protein (PRAME × CD3), in patients with HLA-A*02:01-positive metastatic cutaneous melanoma (mCM) showed the treatment had notable clinical activity. Dr McKean also comments on a Phase I trial (NCT03161431) investigating SX-682, a CXCR1/2 inhibitor, combined with pembrolizumab. This interview took place during the 2024 ASCO Meeting in Chicago, IL.
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Disclosures
Consulting or Advisory Role – Castle Biosciences ; IQVIA ; Merck ; Moderna Therapeutics ; Pfizer
Research Funding – AADi ; Alpine Immune Sciences ; Arcus Biosciences ; Arvinas ; Ascentage Pharma Group ; ASCO ; Astellas Pharma ; Aulos Bioscience ; Bayer ; Bicycle Therapeutics ; BioMed Valley Discoveries ; BioNTech ; Bristol-Myers Squibb ; C4 Therapeutics ; Dragonfly Therapeutics ; EMD Serono ; Epizyme ; Erasca, Inc ; Exelixis ; Foghorn Therapeutics ; G1 Therapeutics ; Genentech ; Gilead Sciences ; GlaxoSmithKline ; IDEAYA Biosciences ; Ikena Oncology ; Immvira ; Infinity Pharmaceuticals ; Jacobio ; Kechow Pharma ; Kezar Life Sciences ; Kinnate Biopharma ; MedImmune ; Mereo BioPharma ; Metabomed ; Moderna Therapeutics ; NBE Therapeutics ; Nektar ; Novartis ; NucMito Pharmaceuticals ; OncoC4 ; Oncorus ; OnKure ; PACT Pharma ; Pfizer ; Plexxikon ; Poseida ; Prelude Therapeutics ; Pyramid Biosciences ; Regeneron ; Sapience Therapeutics ; Scholar Rock ; Seagen ; Synthorx ; Tempest Therapeutics ; TeneoBio ; Tizona Therapeutics, Inc. ; Tmunity Therapeutics, Inc. ; Top Alliance BioScience ; Xilio Therapeutics
