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GU Cancers 2025 | RC48-C017: disitamab vedotin and toripalimab in HER2-expressing MIBC

Xinan Sheng, MD, Peking University Cancer Hospital & Institute, Beijing, China, shares updated results from the Phase II RC48-C017 trial (NCT05297552) of disitamab vedotin and perioperative toripalimab in muscle-invasive bladder cancer (MIBC) with HER2 expression. Promising pathological complete response and event-free survival rates were observed, particularly in HER2 IHC 3+ patients. The safety profile was manageable with no surgery delays. This interview took place at the ASCO GU Cancers Symposium 2025 in San Francisco, CA.

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