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ASCO 2025 | How does tissue-free testing allow rapid and informed treatment decisions?

John Paul Shen, MD, The University of Texas MD Anderson Cancer Center, Houston, TX, speaks on the clinical implications of a tissue-agnostic, methylation-driven minimal residual disease (MRD) platform. Research shows that knowing the MRD status after surgery can predict the benefit of adjuvant chemotherapy, further emphasising the importance of early, informed intervention to increase treatment success. This new approach facilitates, which requires only the drawing of blood to run an assay, enables quicker decision making. This interview took place during the 2025 American Society of Clinical Oncology (ASCO) Meeting in Chicago, IL.

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Transcript

This is particularly important in the real world where we have these same problems in the academic world, but they’re amplified I think in the real world in that getting availability of tissue for sequencing and the time that it takes is problematic. So being able to have an assay that only requires you to draw the patient’s blood speeds this process up considerably...

This is particularly important in the real world where we have these same problems in the academic world, but they’re amplified I think in the real world in that getting availability of tissue for sequencing and the time that it takes is problematic. So being able to have an assay that only requires you to draw the patient’s blood speeds this process up considerably. There is more data presented at this meeting that whether you are MRD positive after your surgery or not is strongly predictive of the benefit of adjuvant chemotherapy. And so, having that answer promptly, not six weeks later, but two weeks later or a week later is actually going to be very important because you need to make decisions about are we going to do chemotherapy or not.

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Disclosures

Stock and Other Ownership Interests – Agios; Syndax; Syndax
Consulting or Advisory Role – Engine Biosciences; NaDeNo Nanosciences
Research Funding – BostonGene; Ikena Oncology (Inst)