ESMO Immuno-Oncology 2025 | The future of intratumoral immunotherapies in solid tumors
Angelica Loskog, PhD, Uppsala University, Uppsala, Sweden, discusses the potential of intratumoral approaches in cancer treatment, noting that as vaccine technologies improve, targeted delivery directly to the tumor site may become more common to minimize side effects and induce a systemic immune response. Dr Loskog highlights the benefits of localized treatment, comparing it to traditional vaccination methods where a localized injection can provide protection against infections in other parts of the body. This interview took place at 2025 European Society for Medical Oncology (ESMO) Immuno-Oncology Congress in London, UK.
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Transcript
I think it will become more common because the intratumoral approach may have sounded a little bit strange for the big pharma companies in the beginning. They are used to giving something intravenously. But when you build stronger and stronger vaccines, in a way, I mean it could be viruses, but it could also be mRNA or something else, then you don’t want to have it everywhere in the body...
I think it will become more common because the intratumoral approach may have sounded a little bit strange for the big pharma companies in the beginning. They are used to giving something intravenously. But when you build stronger and stronger vaccines, in a way, I mean it could be viruses, but it could also be mRNA or something else, then you don’t want to have it everywhere in the body. I mean, when you give a vaccination to someone, you give it in the arm, and then you hope to protect against an infection of the lungs. And I think that’s where we need to get with these types of treatments for cancer, that we can inject one tumor to get an immune response that is systemic. Then we will also spare the patients from a lot of side effects when you treat the whole body and not just the tumor.
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