Benjamin Besse, MD, PhD, Gustave Roussy Cancer Institute, Paris, discusses results from lung cancer trials that are anticipated in 2021. Prof. Besse describes the Phase III CheckMate 816 (NCT02998528) and the Phase III IMpower010 (NCT02486718) trial, which both assess the efficacy of immune checkpoint inhibitors in non-small cell lung cancer (NSCLC) and will help elucidate who will benefit from such treatments. The Phase III J-ALEX trial, which investigates alectinib versus crizotinib in ALK-positive NSCLC, is additionally mentioned. This interview took place at the American Society of Clinical Oncology (ASCO) 2021 Virtual Meeting.