SITC 2022 | The role of tissue tension and myeloid cells in modulating tumor immunity

Kevin Tharp, PhD, University of California, San Francisco, CA, discusses how the physical properties of the tumor microenvironment can influence tumor immunity by regulating the metabolism of myeloid cells. The fibrotic capsule is disintegrated once myeloid cells come into contact with wound-like stiffened tissue in tumors, creating a new extracellular matrix. The process results in the metabolization of arginine into ornithine by myeloid cells, which created an immunosuppressive environment in the tumor. This interview took place at the 37th Annual Meeting of the Society for Immunotherapy in Cancer (SITC 2022) in Boston, MA.

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