Enrique Grande, MD, MD Anderson Cancer Center Madrid, Madrid, Spain, outlines updated data from the Phase III IMvigor 130 trial (NCT02807636) of atezolizumab as monotherapy or in combination with platinum-based chemotherapy in patients with untreated locally advanced or metastatic urothelial carcinoma. Patients who received atezolizumab plus chemotherapy had improved overall survival at 13 months of follow-up, however, this was not statistically significant. Patients who received atezolizumab monotherapy and were PD-L1 positive had improved overall survival. This interview took place at the virtual American Association for Cancer Research (AACR) Annual Meeting 2021.