Sofia Rivera, MD, PhD, Gustave Roussy, Villejuif, France, provides an overview of the the Phase III HypoG-01 (NCT03127995) trial compared hypofractionated (HF) radiation therapy (RT) with normofractionated (NF) RT in loco-regional early breast cancer (EBC) to assess the risk of arm lymphedema. The study included 1,221 patients who received either HF RT (40 Gy/15 fr) or NF RT (50 Gy/25 fr). The primary endpoint was the occurrence of arm lymphedema after RT. The results showed that HF RT was non-inferior to NF RT in terms of lymphedema risk, with a 3-year rate of 24.1% in the HF group and 22.6% in the NF group. The study provides level 1A evidence supporting the use of 40 Gy/15 fr for loco-regional radiation therapy in EBC to minimize the risk of arm lymphedema. This interview took place at the ESTRO congress in Vienna, Austria.
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