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ASCO 2024 | WU-KONG1: sunvozertinib in NSCLC with EGFR exon 20 insertion mutations
James Chih-Hsin Yang, MD, MPH, National Taiwan University, Taipei, Taiwan, discusses findings from the Phase II WU-KONG1 study (NCT03974022) of sunvozertinib in pre-treated patients with EGFR exon 20 insertion-mutated (exon20ins) non-small cell lung cancer (NSCLC). Objective response rates (ORR) were higher than in previous studies that assessed amivantamab or mobocertinib. Safety findings indicate manageable treatment-related adverse events. The results support sunvozertinib as a promising treatment for this patient population. This interview took place during the 2024 American Society of Clinical Oncology (ASCO) Meeting in Chicago, IL.
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Disclosures
Honoraria – Amgen; AstraZeneca; AstraZeneca/MedImmune; BeiGene; Boehringer Ingelheim; Boehringer Ingelheim; Bristol-Myers Squibb; Daiichi Sankyo/Astra Zeneca; Dizal Pharma; Gilead Sciences; Lilly; MSD; MSD Oncology; Novartis; Ono Pharmaceutical; Pfizer; Pfizer; Roche; Roche/Genentech; Sanofi/Regeneron; Taiho Pharmaceutical; Takeda; Takeda
Consulting or Advisory Role – Abbvie; Amgen; Amgen; AstraZeneca; AstraZeneca; Bayer; Bayer; Blueprint Medicines; Boehringer Ingelheim; Boehringer Ingelheim; Bristol-Myers Squibb; Celgene; Clovis Oncology; Daiichi Sankyo; Daiichi Sankyo/Astra Zeneca; G1 Therapeutics; Gilead Sciences; GlaxoSmithKline; Hansoh; Incyte; Janssen Oncology; Lilly; Merck KGaA; MSD Oncology; MSD Oncology; Novartis; Novartis; Ono Pharmaceutical; Pfizer; Pfizer; Puma Biotechnology; Roche/Genentech; Sanofi; Taiho Pharmaceutical; Takeda; Takeda; Yuhan
Research Funding – AstraZeneca
Travel, Accommodations, Expenses – Pfizer
