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ASCO 2023 | Radiation and adjuvant nivolumab in HPV+ oropharynx cancer

Heath Devin Skinner, MD, PhD, Hillman Cancer Center, Pittsburgh, PA, discusses findings from the Phase II study (NCT03715946), which aimed to investigate treatment de-intensification for resected human papillomavirus (HPV)-associated oropharyngeal squamous cell carcinoma (OPSCC) by adding nivolumab to a reduced radiation therapy (RT) regimen. Eligible patients had high-risk factors and underwent transoral resection. Treatment consisted of accelerated fractionation RT with concurrent nivolumab, followed by adjuvant nivolumab for 6 months. The primary endpoint was progression-free survival (PFS). The study demonstrated that this de-intensified treatment approach combining nivolumab with RT was well-tolerated and showed favorable clinical outcomes for patients with high-risk, resected HPV+ OPSCC. This interview took place at the American Society of Clinical Oncology (ASCO) 2023 Annual Congress in Chicago, IL.

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