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Marc Mureau MD, PhD of Erasmus University Medical Center, Rotterdam, Netherlands discusses the challenges associated with treating patients with head and neck cancer. The primary challenge is that the head and neck are very functional areas, replacing tissues in a three-dimensional way to allow function is difficult. Sequential radiotherapy can also have a negative impact on function of the affected area. Dr Mureau describes how surgical techniques have developed over time to become more complex and allow for sophisticated procedures to be performed with reduced complications and better patient outcomes. Recorded at the European Cancer Congress of the European Cancer Organisation (ECCO) 2017 in Amsterdam, Netherlands.