AACR 2023 | GUK1 as a driver of resistance to targeted therapies in lung cancer

Jaime Schneider, MD, PhD, Dana-Farber Cancer Institute, Boston, MA, discusses the role of GUK1, a guanylate kinase, in the resistance to targeted therapies in lung cancer. Resistance to targeted therapies is currently an unmet need, and GUK1 was identified as a novel metabolic liability in a radiomic and metabolic analysis. Post-translational modification of the enzyme enables tumor proliferation, and is mainly observed in ALK-driven lung cancer. This interview took place at the American Association for Cancer Research (AACR) Annual Meeting 2023 in Orlando, FL.

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